Aging is not linear, and its mechanisms are in place many years before the signs of aging appear.
Aging begins when tissues and organs begin to lose function as a result of cell degradation, or senescence. Some organs, such as the skin, see certain functions begin to decline, while others, such as the brain, are still developing.
However, there is a consensus that aging begins between the ages of 25 and 35.
Based on the evolution of 5 parameters (metabolism, bone structure, muscles, memory, sleep) in 4,263 people aged between 18 and 95, researchers have shown that aging is not linear, but progresses in 3 stages: 30, 60 and 78 (1).
The mechanisms of aging are in place for a long time, sometimes decades, before the first signs of aging appear.
The average age of the first consultation with anti-aging medicine is 45 – 50, i.e. the age of the established signs of aging.
Based on experimental studies showing that anti-aging treatments, such as Metformin, are more beneficial if started early in life (2), some specialists are leaning towards early management of aging, as early as 25 – 30 years old, starting with a complete check-up.
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(1) : T. Wyss-Coray et Al. Undulating changes in human plasma proteome profiles across the lifespan. Nat Med. 2019 Dec; 25(12): 1843–1850. doi: 10.1038/s41591-019-0673-2
(2) : V. Anisimov. If started early in life, metformin treatment increases life span and postpones tumors in female SHR mice. Aging (Albany NY). 2011 Feb; 3(2): 148–157. doi: 10.18632/aging.100273
