Aging, glycation, what’s new? Menopause, hot flashes, glycation. An update on some surprising links.

A symbolic menopausal inconvenience, hot flushes can be considerably reduced by combating glycation.

Hot flushes are the major inconvenience of the menopause. They come on suddenly, sometimes up to 20 times a day. Reputedly harmless, they decrease over time.

Their main cause is hormonal deficiency, aggravated by environmental and behavioral factors.

Under strict medical supervision, hormone replacement therapy can reduce hot flushes and other menopausal effects.

It has been observed that the frequency of hot flushes has doubled in the last 50 years (1).

In 2023, researchers showed that a diet low in glycation products (AGEs) – no industrial food, no added sugar – is associated with a significant reduction in the frequency of post-menopausal hot flushes after 12 weeks, even in severe cases (2). The lower the diet in AGEs, the better the results!

These results corroborate the association already observed between cardiovascular risk and severe hot flushes, making them a marker of risk for accelerated ageing.

Combating glycation through lifestyle interventions, notably a low-sugar diet and deglycating supplementation, appears to be a promising strategy for overcoming, in a few weeks, the major inconvenience of hot flushes during menopause.

© AGE Breaker 03 2024

[Glycation is one of the major causes of aging. Resulting from the fixation of sugars on the proteins constituting the organism, glycation generates toxic compounds that cause cellular aging. Glycation is particularly involved in metabolic disorders, skin aging and cognitive decline.]
[AGE BREAKER, patented nutritional supplements, based on rosmarinic acid, recognized by aging specialists around the world for their properties to reverse the effects of glycation.]

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(1): RÖDSTRÖM, Kerstin, WEMAN, Lilian, SUNDH, Valter, et al. Perception of higher frequency of daily hot flashes in 50-year-old women today: a study of trends over time during 48 years in the Population Study of Women in Gothenburg, Sweden. Menopause, 2022, vol. 29, no 10, p. 1124-1129. DOI: 10.1097/GME.000000000000203

(2): KAHLEOVA, Hana, ZNAYENKO-MILLER, Tatiana, URIBARRI, Jaime, et al. Dietary advanced glycation end-products and postmenopausal hot flashes: a post-hoc analysis of a 12-week randomized clinical trial. Maturitas, 2023, vol. 172, p. 32-38.