A high level of glycation, a marker of aging, would increase the risk of transmission of the metabolic syndrome between mother and child, thus announcing an uncontrollable increase in cases of premature aging.
A study conducted among pregnant women shows that a high glycation rate is associated with the macrosomia of their children (1). Of 343 pregnant women with a metabolic syndrome or gestational diabetes, 11% of them, with the highest glycation levels, gave birth to a macrosomic child (birth weight over 4 kg).
A detailed analysis of the results shows that their average glycation rate was equivalent to a 50-year-old, about 15 years older than their chronological age (33 years on average).
The mechanism of transmission is not known but likely involves epigenetic.
These results are particularly worrying. As the metabolic syndrome has reached epidemic levels in many countries among reproductive age women, the birth rate of overweight children will increase mechanically. Knowing that a high birth weight is a risk factor for the occurrence of the metabolic syndrome throughout life, the epidemic of metabolic syndrome will reach more or less long-term uncontrollable levels.
© AGE BREAKER, update 11 2021
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1: N. Foussard et Al. Skin Autofluorescence of Pregnant Women With Diabetes Predicts the Macrosomia of their Children. Diabetes 2019 Aug;68(8):1663-1669. doi: 10.2337/db18-0906. Epub 2019 May 24.
