Long-term studies show that intensive lifestyle intervention is more effective than medication in preventing metabolic syndrome and accelerated aging.
Abdominal overweight is a precursor sign of metabolic syndrome, diabetes and, more generally, accelerated aging. It’s easy to identify subjects at risk, monitor them and measure the effectiveness of strategies preventing accelerated aging.
Studies conducted by the National Diabetes Prevention Program in the United States on at-risk populations over long periods of time show that preventive use of geroprotective drugs such as metformin significantly reduces (by around 30%) the onset of diabetes (1).
The same studies show that intensive lifestyle intervention – strict diet and exercise, with follow-up – can reduce the risk of developing diabetes by 58%, and by up to 71% for people over 60 (2).
These results suggest that intensive lifestyle intervention may be more effective than pharmacological treatment in preventing diabetes and thus accelerated aging.
© AGE Breaker, updated 11 2023
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(1) : U. Hostalek et Al (2021) Metformin for diabetes prevention: update of the evidence base, Current Medical Research and Opinion, 37:10, 1705-1717, DOI:10.1080/03007995.2021.1955667
(2) : www.cdc.gov/diabetes/prevention/about.htm. Last update 11 2023
