GLYCATION GLYCATION & METABOLISM

Best of / Overweight: towards a pandemic of accelerated aging?

Being overweight promotes aging (1). Its increase throughout the world, in ever younger populations, presages an upheaval in accelerated aging.

Overweight and obesity affect about 70% of the adult population in the United States and even more in Mexico; it is estimated at 40% in France, Italy and Switzerland. More seriously, overweight and obesity among 15-year-old adolescents has been steadily increasing since the 2000s: more than 30% of North American adolescents today; already 12% in France.

At the same time, obesity and diabetes are increasingly affecting young people. First described in the United States in the early 2000s, type 2 diabetes in children is growing in virtually every part of the world.

Even more seriously: new studies suggests that small children with a rapid increase in body mass before age 3, a period normally characterized by a decrease in BMI, are likely to develop cardiometabolic risk later in life (2).

Long protected by their traditional diet, Mediterranean populations are being swept away by the surge of childhood “diabesity”. More than 20% of Greek adolescents are now overweight!

Only Japan, India and Korea seem to be resisting this global pandemic.

Before epigenetics worsens this situation, it is urgent.

Preventive measures exist, diet, physical exercise… but they are of no use without the awareness of the people concerned who are unaware of their condition. Faced with the announced disaster, the strategy to adopt is to practice systematic screening. Whatever the age, the slightest overweight must trigger the alert.

© AGE Breaker 04 2023

[Glycation is one of the major causes of aging. Resulting from the fixation of sugars on the proteins constituting the organism, glycation generates toxic compounds that cause cellular aging. Glycation is particularly involved in metabolic disorders, skin aging and cognitive decline.]
[AGE BREAKER, patented nutritional supplements, based on rosmarinic acid, recognized by aging specialists around the world for their properties to reverse the effects of glycation.]

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Statistical sources:

https://stats.oecd.org/Index.aspx?ThemeTreeId=9

http://www.oecd.org/health/obesity-update.htm 2017

(1): Bentley RA et Al. Obesity, Metabolism, and Aging: A Multiscalar Approach. Prog Mol Biol Transl Sci.  2018;155:25-42. doi: 10.1016/bs.pmbts.2017.11.016.

(2): O.Arisaka et Al.Childhood obesity: rapid weight gain in early childhood and subsequent cardiometabolic risk. Clinical Pediatric Endocrinology 29 (2020) https://doi.org/10.1297/cpe.29.135