Cognitive impairment would be directly associated with AGEs.
Schizophrenia is a complex psychiatric pathology characterized by significant deficits in attention and disturbed behavior. Clinical observation shows problems with the fluidity of thought and the adjustment of behavior to the context.
A first study showed a correlation between the level of glycation, schizophrenia and its severity (1).
A recent Japanese study of 58 schizophrenic patients established a link between glycation and cognitive impairment and shows that it is cognitive fluency that is affected by AGEs (2).
These findings could lead to new diagnostic and treatment strategies. Interventions to reduce glycation may help promote recovery in patients with schizophrenia.
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1 – Y. kouidrat et Al. Increased advanced glycation end-products (AGEs) assessed by skin autofluorescence in schizophrenia. Journal of Psychiatric Research. Volume 47, Issue 8, August 2013, Pages 1044-1048.
Doi.org/10.1016/j.jpsychires.2013.03.016
2 – Akiko Kobori et AL. Advanced glycation end products and cognitive impairment in schizophrenia. PLoS One. 2021; 16(5): e0251283. Published online 2021 May 26. Doi:10.1371/journal.pone.0251283
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