Deglycation of the muscle matrix: a way to treat sarcopenia?
Aging leads to deleterious changes in skeletal muscles including muscle atrophy, increased intramuscular collagens which, above a certain level, results in the age-related muscle wasting pathology known as sarcopenia.
It is now accepted that the glycation of these intramuscular collagens, leading to the accumulation of AGEs (Advanced Glycation End-products), plays a key role in the acceleration of sarcopenia (1).
Particularly interesting, a successful deglycation attempt, on decellularized muscle matrix from mice (2) using an AGE Cross Link Breaker molecule, opens the way for future studies on the management of sarcopenia.
© Age Breaker 01 2022
[AGE BREAKER, patented nutritional supplements, based on rosmarinic acid, recognized by aging specialists around the world for their properties to reverse the effects of glycation.] [Glycation is one of the major causes of aging. Resulting from the fixation of sugars on the proteins constituting the organism, glycation generates toxic compounds that cause cellular aging. Glycation is particularly involved in metabolic disorders, skin aging and cognitive decline.]More on www.agebreaker.com
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1 – L. C. Olson et Al. Advanced Glycation End-Products in Skeletal Muscle Aging. Bioengineering 2021, 8(11),168;
Doi.org/10.3390/bioengineering8110168
2 – L. C. Olson et Al. Advanced Glycation End Products Are Retained in Decellularized Muscle Matrix Derived from Aged Skeletal Muscle.
Int. J. Mol. Sci. 2021, 22(16), 8832;
Doi.org/10.3390/ijms22168832
Crédit photo ; iamnickbauer .
