Failure to respect the biological rhythms of diet and sleep leads to poor glucose metabolism.
Our body has its own biological clocks, based on a circadian rhythm of around 24 hours.
These biological rhythms, specific to each organ, enable the body to adapt to foreseeable daily changes, such as the alternation of day and night, or eating and fasting.
The disruption of certain rhythms can have serious consequences for health.
For example, circadian regulation of glucose metabolism, a key factor in age-related diseases, is regulated so that glucose is better tolerated in the morning than in the afternoon or evening. The extent of circadian variation in glucose tolerance is surprisingly large: the same dose of glucose, normally tolerated in the morning, may have pathological-level metabolic consequences in the evening (1).
Circadian misalignment, induced by a high glycemic index diet in the evening, increases the risk of developing metabolic diseases such as diabetes, as well as accelerated aging.
Worse still, circadian misalignment induced by inappropriate exposure to light at night also affects glucose metabolism and metabolic health.
More seriously, these metabolic deteriorations in turn lead to a decline in circadian clock function.
The spiral of aging; to be continued…
© AGE Breaker, updated 11 2023
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(1): E. Poggiogalle et al. Circadian regulation of glucose, lipid, and energy metabolism in humans. Metabolism 2018 Jul; 84:11-27. DOI: 10.1016/j.metabol.2017.11.017
