GLYCATION GLYCATION & METABOLISM

Metabolic syndrome: the insidious pandemic!

Metabolic syndrome is a set of risk factors for accelerated aging and age-related diseases. Its rapid and boundless spread heralds a global health catastrophe.

Metabolic syndrome is a series of health problems that significantly increases the risk of age-related diseases (diabetes, cardiovascular disease and stroke, certain cancers), weakens the immune system and accelerates aging.

We talk of metabolic syndrome when a person with abdominal obesity has at least two of the following factors:
Hyperglycaemia, high triglycerides, low HDL cholesterol, high blood pressure.

Metabolic syndrome affects 25% to 30% of the adult population in Europe. It is progressing rapidly throughout the world, affecting younger and younger people.
Most people with metabolic syndrome are unaware of their condition.

Extrinsic factors, such as junk food and a sedentary lifestyle, as well as epigenetic and genetic factors, are the main causes of metabolic syndrome.

A growing number of studies show that glycation, resulting from over-consumption of sugar, plays a central role in the genesis and aggravation of metabolic syndrome (1, 2, 3).

The good news is that metabolic syndrome is reversible and can be reprogrammed by adopting a specific lifestyle from the outset:
– Daily physical exercise,
– Preventive diet (reducing sugars, favouring foods with a low glycaemic index),
– Controlling stress and sleep.
Glycation-targeted nutritional supplements help control metabolic syndrome.

© AGE Breaker updated 02 2025

[Glycation is one of the major causes of aging. Resulting from the fixation of sugars on the proteins constituting the organism, glycation generates toxic compounds that cause cellular aging. Glycation is particularly involved in metabolic disorders, skin aging and cognitive decline.] [AGE BREAKER, patented nutritional supplements, based on rosmarinic acid, recognized by aging specialists around the world for their properties to reverse the effects of glycation.]

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(1): VAN WAATERINGE, Robert P., SLAGTER, Sandra N., VAN BEEK, Andre P., et al. Skin autofluorescence, a non-invasive biomarker for advanced glycation end products, is associated with the metabolic syndrome and its individual components. Diabetology & metabolic syndrome, 2017, vol. 9, p. 1-12.
https://doi.org/10.1186/s13098-017-0241-1

(2): SERGI, Domenico, BOULESTIN, Hakim, CAMPBELL, Fiona M., et al. The role of dietary advanced glycation end products in metabolic dysfunction. Molecular Nutrition & Food Research, 2021, vol. 65, no 1, p. 1900934.
doi: 10.1002/mnfr.201900934.

(3) : TIRELLI, Emanuela, PUCCI, Mariachiara, SQUILLARIO, Margherita, et al. Effects of Methylglyoxal on Intestine and Microbiome Composition in Aged Mice. Food and Chemical Toxicology, 2025, p. 115276.
doi: https://doi.org/10.1101/2025.01.24.634754