With its metabolism disrupted by an unsuitable lifestyle, glucose – the brain’s fuel – becomes one of the driving forces of cerebral senescence.
Glucose is the brain’s main source of energy. Neurons, which neither produce nor store glucose, consume up to 25% of the energy derived from glucose. This implies a tight, fragile coupling between energy demand and supply, involving in particular glucose-transporting proteins.
Over-consumption of sugar disrupts this mechanism.
Studies have shown that cognitive impairment in Alzheimer’s disease is associated with abnormal glucose metabolism, notably due to alterations in glucose transporter proteins (1). A progressive decline in glucose metabolism would thus be an early marker of Alzheimer’s disease.
This opens the way to glucose metabolic reprogramming, based on intensive lifestyle intervention (diet, supplementation, exercise, sleep, stress…) as a new perspective in the treatment and prevention of neuronal senescence and other age-related diseases.
© AGE Breaker, updated 12 2023
[Glycation is one of the major causes of aging. Resulting from the fixation of sugars on the proteins constituting the organism, glycation generates toxic compounds that cause cellular aging. Glycation is particularly involved in metabolic disorders, skin aging and cognitive decline.] [AGE Breaker, patented nutritional supplements, based on rosmarinic acid, recognized by aging specialists around the world for their properties to reverse the effects of glycation.]More on www.agebreaker.com
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(1) : Q. Wang et Al. Glucose Metabolism, Neural Cell Senescence and Alzheimer’s Disease. Int. J. Mol. Sci. 2022, 23(8),4351;
