Dr Jana Janovska MD, PhD,
Dermatologist, Riga, Latvia.
Abstract:
Introduction:
Accumulation of advanced glycation endproducts (AGEs) is linked with development or aggravation of many degenerative processes or disorders. AGEs production in skin cells is known to promote stiffness and loss of elasticity through their build up in connective tissue. Glycation is a slow, non enzymatic reaction that takes place between free amino groups in proteins primarily from lysine and a reducing sugar (glucose and ribose). AGES provoke biological modifications implying an activation of matrix degradation. AGEs are implicated in pigmentation associated with photo aging. AGE-mediated melanogenesis may thus hold promise as a novel mean of altering skin pigmentation. Exposure of AGEs to UVA irradiation leads to formation of ROS. They can compromise cellular antioxidant defense systems.
Accumulation of AGEs in the skin is detected not only in diabetes as expected but also during chronological aging.
Conclusion:
AGEs accumulation in the skin shows more expressed clinical aging related changes (seborrhoeic and actinic keratosis, telangectasia, deep wrinkles…).
Metabolic syndrome is a factor of excess of ROS and reduced antioxidant activity.
AGEs accumulation is associated with inflammatory process.
AGEs are associated with metabolic syndrome, hypercholesterolemia, increased BMI…
AGEs accumulation in the skin shows more expressed clinical aging related changes (seborrhoeic and actinic keratosis, telangectasia, deep wrinkles…).
Revue de communications scientifiques réalisée par Thomas Josse (leblogdethomasjosse.blogspot) pour Insideagebreaker.org
Crédit photo :Giuseppe Arcimboldo « art selfie »
