Glycation is promoted by genetic and behavioral factors. Its mechanisms and consequences, cellular aging and diseases associated with aging, could be transmitted to future generations by epigenetic means.
An extension of genetics, epigenetics is a branch of biology that focuses on the involvement of genetics and the environment in understanding the transmission of acquired traits.
Thus, studies have shown the role of epigenetics in the phenomenon of metabolic memory in diabetes (1).
Likewise, foetal exposure to maternal glycation, as a result of eating too much sugar before pregnancy, may be associated with a higher risk of glycation in children. Risk greater than that attributable to genetic factors. We would then see a maternal transmission of the risks of accelerated aging (2).
And this is how a diet too rich in sugar would have irreversible consequences
on the aging of future generations.
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[Glycation is one of the major causes of aging. Resulting from the fixation of sugars on the proteins constituting the organism, glycation generates toxic compounds that cause cellular aging. Glycation is particularly involved in metabolic disorders, skin aging and cognitive decline.] [AGE BREAKER, patented nutritional supplements, based on rosmarinic acid, recognized by aging specialists around the world for their properties to reverse the effects of glycation.]More on www.agebreaker.com
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(1): A.El-Osta et al. Transient high glucose causes persistent epigenetic changes and altered gene expression during subsequent normoglycemia. The Journal of Experimental Medicine. 2008; doi: 10.1084 / jem.20081188092608c
(2): Anna Perrone et Al. Advanced Glycation End Products (AGEs): Biochemistry, Signaling, Analytical Methods, and Epigenetic Effects. Oxidative medicine and cellular longevity. Published online 2020 Mar 18. doi: 10.1155/2020/3818196
