By attacking the intestinal microbiota, glycation could have unexpected consequences for overall health.
The intestinal microbiota, made up of micro-organisms living in the digestive tract, has long been thought to be limited solely to the digestion of food.
However, DNA sequencing in the early 2000s has revealed many essential functions of the intestinal microbiota: modulation of immunity, influence on the brain, and involvement in numerous metabolic diseases, allergies and other disorders.
Made up of billions of micro-organisms of very diverse origins, it is now recognised as an ‘invisible organ’ essential to health.
For the first time, researchers have demonstrated, in a preclinical study, that the formation of glycated proteins in the intestine alters its homeostasis (1).
Resulting from the consumption of sugar or industrial food rich in sugars, this endogenous glycation disrupts the intestinal barrier and induces changes in the composition of the intestinal microbiota.
By attacking the intestinal microbiota, glycation, known for its deleterious effects on proteins with a slow turnover rate, is demonstrating that it can spread rapidly throughout the body by disrupting intestinal homeostasis.
We can expect new consequences linked to the over-consumption of sugars, notably on immune cell responses and interactions between the intestine and the brain, as well as metabolic diseases.
© AGE Breaker 01 2025
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(1) : TIRELLI, Emanuela, PUCCI, Mariachiara, SQUILLARIO, Margherita, et al. Effects of Methylglyoxal on Intestine and Microbiome Composition in Aged Mice. Food and Chemical Toxicology, 2025, p. 115276.
https://doi.org/10.1016/j.fct.2025.115276
