Glycation is thought to be one of the causes of age-related frailty.
Frailty is a clinical state of vulnerability to aging. Frailty is associated with aging, but not necessarily with a chronic health problem.
Very easy to detect, frailty comprises 5 components: weight loss, poor grip strength, fatigue, slow walking, non-activity.
Frailty is a progressive condition, potentially reversible if detected early.
Approximately 10% of people over 65 show signs of frailty.
A Japanese study of 559 people with an average age of 67 (from 57 to 77) revealed a link between glycation, frailty and cognitive decline. The conclusion of this study suggest that glycation is one of the causes of age-related frailty (1).
Usually practiced in gerontology, often from the age of 70, frailty screening could be used in anti-aging medicine much earlier, with some specialists suggesting as early as 55. The slightest deviation would lead to the management of aging, notably by adopting a healthy lifestyle to combat glycation (diet with low glycemic index, no added sugar, supplements, physical exercise, etc.).
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(1) : TAKEI, Satoko, OCHI, Masayuki, SHIRAOKA, Akira, et al. Frailty and aging are associated with cognitive decline and dermal advanced glycation end-product accumulation in older Japanese men. Archives of Gerontology and Geriatrics Plus, 2024, p. 100071.
https://doi.org/10.1016/j.aggp.2024.100071
