Glycation may explain why sleep deprivation increases cardiovascular risks.
Sleep duration varies according to age, culture and lifestyle. Numerous studies show a steady decline in this sleep duration, particularly in the Western world, where average sleep time has fallen by 1.5 hours in 50 years.
Sleep is recognized as a key factor in good health. Thus, validating the association between sleep deprivation and cardiovascular risk, the American Heart Association has included sleep as a component of the cardiovascular health score. The causal relationship has yet to be established.
By analyzing associations between sleep duration and biomarkers of cardiovascular risk, researchers have shown a correlation between sleep duration and glycation (1). Glycation increased significantly when sleep duration fell below 6 hours per night.
These results confirm that insufficient sleep increases cardiovascular risk.
Although this remains to be proven, it is reasonable to assume that sleep deprivation is a cause of increased glycation. Glycation, resulting from over-consumption of sugar, is one of the main factors in aging. Sleep deprivation would therefore be an accelerator of aging.
To be continued…
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(1) : MARTÍNEZ-GARCÍA, Irene, SAZ-LARA, Alicia, CAVERO-REDONDO, Iván, et al. Association between sleep duration and cardiovascular risk: the EVasCu cross-sectional study. Frontiers in Physiology, 2024, vol. 15, p. 1430821.