The intestinal microbiota contributes to brain aging via glycation.
The discovery of the interactions between the intestinal microbiota, made up of the countless microorganisms of the digestive tract, and the brain is probably one of the major recent discoveries. Some speak of the gut as a second brain.
A recent study reveals the role of the gut in neurological dysfunction associated with aging (1).
At the heart of this mechanism, CML (CarboxyMethylLysine), an AGEs (Advanced Glyation Endproduct).
The hypothesis would be that the aging intestinal microbiota, by altering the permeability of the digestive system, would allow AGEs to infiltrate through the body, including as far as the brain…
© AGE Breaker 02 2023
✅ [AGE Breaker, patented nutritional supplements, based on rosmarinic acid, recognized by aging specialists around the world for their properties to reverse the effects of glycation.]
✅ [Glycation is one of the major causes of aging. Resulting from the fixation of sugars on the proteins constituting the organism, glycation generates toxic compounds that cause cellular aging. Glycation is particularly involved in metabolic disorders, skin aging and cognitive decline.]
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(1): O. Mossad et Al. Gut microbiota drives age-related oxidative stress and mitochondrial damage in microglia via the metabolite N 6 carboxymethyllysine. Nat Neurosci. 2022 Mar;25(3):295-305. Doi: 10.1038/s41593-022-01027-3.
