A diet rich in glycation would promote the aggressive growth of prostate tumors.
While the effects of glycation on aging and aging-related diseases are becoming well understood, the implications between glycation and cancer are poorly defined.
A recent original study (1) on in vivo, ex vivo and in vitro models shows that a diet rich in AGEs (glycation-derived compounds), such as western junk food, promotes the aggressive growth of prostate tumours.
It should be noted in these cases that the glycation provided exogenously (food rich in preformed AGEs) has a much greater impact than endogenous glycation (diet rich in sugar only).
It should also be noted that once tumor growth is established, the interruption of the diet rich in AGEs has no effect on the evolution of the tumour.
This study attributes to exogenous glycation a significant oncogenic potential. Consequently, a nutritional strategy aimed at reducing AGEs can be considered as a new chemo-preventive initiative.
© AGE BREAKER 02 2022
Crédit photo ; @artszhao
1 – B.A. Krisanits et Al. Non-enzymatic glycoxidation linked with nutrition enhances the tumorigenic capacity of prostate cancer epithelia through AGE mediated activation of RAGE in cancer associated fibroblasts.
Original research. Translational Oncology. Volume 17, March 2022. Available online 25 January 2022. Doi.org/10.1016/j.tranon.2022.101350
