Long-term studies show that lifestyle and dietary measures are more effective than drug treatments in preventing metabolic syndrome and biological aging.
Aggravated by glycation, abdominal obesity is a precursor to the metabolic syndrome, consecutively diabetes and more generally early aging. It is therefore easy to identify at-risk individuals, monitor them and measure the effectiveness of anti-metabolic syndrome strategies.
Numerous studies carried out all over the world, over long periods (sometimes more than 20 years), on at-risk populations, show that diet and lifestyle measures can halve the onset of diabetes.
The same type of study shows that taking preventive medicine also helps to reduce the occurrence of diabetes, but to a lesser extent (around 30%). This is the case for Metformin, probably the most studied molecule in diabetes prevention.
A recent study of more than 22,000 people shows that 4 lifestyle factors (lack of tobacco, absence of abdominal obesity, Mediterranean-type diet and exercise) greatly increase the expectation in all subjects including at risk of metabolic syndrome (1).
Since the protective effect of lifestyle changes affecting diet and exercise is widely demonstrated, the prevention of aging linked to the metabolic syndrome must favor hygiene and dietary measures.
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(1): M. Bonaccio and al. Impact of combined healthy lifestyle factors on survival in an adult general population and in high-risk groups: prospective results from the Moli-sani Study. Department of Epidemiology and Prevention, IRCCS Neuromed, Pozzilli, IS, Italy. J. Intern Med. Apr 201