GLYCATION & SKIN

AGE SPOTS, SUN AND GLYCATION, dangerous connections

27 March 2020

Some dark spots are a mark of skin aging. They result from the disruption of two pigment mechanisms and aggravating factors including glycation.

 

1 – Acceleration of melanogenesis:

Melanin is a brown pigment that gives the skin its natural color. Its role is to protect the skin against UVs. With age, repeated exposure to UVs causes a disruption of melanogenesis and leads to the formation of pigment spots.It has been observed that AGEs (Advanced Glycation Products) are capable of stimulating melanogenesis (1). In addition, UV exposure increases glycation which, in turn accelerates photoaging already in progress.

2 – Accumulation of lipofuscins:

Lipofuscin is a brown pigment composed of cellular debris linked to aging factors and in particular oxidation and glycation.It has been observed that lipofuscins have the characteristic of accumulating on cells subject to glycation (2).Glycation is at the heart of a vicious circle associating aging and age spots.
Repairing and preventing age spots linked to aging involves glycation control: reducing the consumption of sugars, taking deglycating nutritional supplements, ensuring permanent photoprotection.
©AGE BREAKER 03 2020
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(1) : Lee, Eun Jung et al. “Advanced glycation end products (AGEs) promote melanogenesis through receptor for AGEs.” Scientific reports vol. 6 27848. 13 Jun. 2016, doi:10.1038/srep27848.
(2) : Skoczyńska A et al. “Melanin and lipofuscin as hallmarks of skin aging”. Postepy Dermatol Alergol. 2017;34(2):97–103. doi:10.5114/ada.2017.67070
Photo ; the_invisible_realm

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